As contrary as it sounds, ´´planning´´ - as we traditionally understand the term - can be the worst thing a company can do. Consider that volatile weather events disrupt trusted supply chains, markets, and promised delivery schedules. Ever-shifting geopolitical tensions as well as internal political upheaval within US and global governments derail long-planned new ventures. Technology failures block opportunities. Competitors suddenly change their products or release dates; your team cannot meet the pace of innovations in your market niche, leaving you sidelined. There are myriad ways in the current business environment for a company´s well-considered business plans to go awry. Most business schools continue to prepare managers to be effective in stable and predictable environments, conditions that, if they ever existed at all, are long gone. The Agility Shift shows business leaders exactly how to make the radical mind-set and strategy shift necessary to create an agile, entrepreneurial organization that can innovate and thrive in complex, ever-changing contexts. As author Pamela Meyer explains, there is much more involved than a reconfiguration of the org chart and job descriptions. It requires relinquishing the illusion of control at the very foundation of most management training and business practice. Despite most leaders´ approaches, ´´Agility is not simply accelerated planning.´´ Unlike many agility books on the market, The Agility Shift provides specific, actionable strategies and tactics for leaders at all levels of the organization to put into practice immediately to improve agility and achieve results. PLEASE NOTE: When you purchase this title, the accompanying reference material will be available in your Library section along with the audio. 1. Language: English. Narrator: Karen Saltus. Audio sample: http://samples.audible.de/bk/gdan/001798/bk_gdan_001798_sample.mp3. Digital audiobook in aax.
Mitochondrial DNA is constantly exposed to, and damaged by oxygen radicals generated by Electron Transport Chain. This damage can lead to a loss of genetic information about key proteins in the ETC. What may follow is a dysfunction in cellular energy production and cell death, unless it is repaired. An efficient DNA repair mechanism in mitochondria keeps the amount of damage at an acceptably low level. The research in this book explores the ways to modulate the efficiency of mtDNA repair and evaluates its contribution to the overall cell survival. Introduction of Exonuclease III from E.coli into human mitochondria, either through stable transfection, or by protein transduction leads to a disruption of an efficient mtDNA repair and renders cells more sensitive to the oxidative stress. Modulation of mtDNA repair in this way can be a potentially useful treatment strategy for pathological conditions were a destruction of abnormal cells is a desired outcome, as in anticancer therapy. This work may be of interest to students or professionals working in the field of mtDNA repair.
For decades, American foreign policy has been based on the seductive belief that there exists a logical relationship between power of states and the physics of change. And yet today policies designed to make us safer instead make the world more perilous. History´s grandest war against terrorism creates more terrorists. Global capitalism, intended to boost the quality of life of people around the world, increases the gap between rich and poor. Decisions taken to stem a financial crisis guarantee its arrival. Environmental techniques engineered to protect species lead to their extinction. Middle East peace plans produce less peace. Our world is not becoming more stable or flatter or easier to comprehend. And what we face isn´t one single shift, like the end of World War Two or the collapse of the Soviet Union, so much as a revolutionary avalanche of ceaseless change. Now, drawing upon history, economics, complexity theory, human immunology, psychology and his own extraordinary experiences, Joshua Ramo puts forth a radical new model for looking at the world, one that embraces its inherent unpredictability--and offers our best hope for dealing with problems and disasters as they emerge. 1. Language: English. Narrator: Joshua Cooper Ramo. Audio sample: http://samples.audible.de/bk/hach/000237/bk_hach_000237_sample.mp3. Digital audiobook in aax.
´´Speak softly and carry a big stick´´, Theodore Roosevelt famously said in 1901 when the United States was emerging as a great power. It was the right sentiment, perhaps, in an age of imperial rivalry. But today many Americans doubt the utility of their global military presence, thinking it outdated, unnecessary, or even dangerous. In The Big Stick, Eliot A. Cohen - a scholar and practitioner of international relations - disagrees. He argues that hard power remains essential for American foreign policy. While acknowledging that the United States must be careful about why, when, and how it uses force, he insists that its international role is as critical as ever, and armed force is vital to that role. Cohen explains that American leaders must learn to use hard power in new ways and for new circumstances. The rise of a well-armed China, Russia´s conquest of Crimea and Eastern Ukraine, nuclear threats from North Korea and Iran, and the spread of radical Islamist movements like ISIS are some of the key threats to global peace. If the United States relinquishes its position as a strong but prudent military power and fails to accept its role as the guardian of a stable world order, we run the risk of unleashing disorder, violence, and tyranny on a scale not seen since the 1930s. The United States is still, as Madeleine Albright once dubbed it, ´´the indispensable nation´´. 1. Language: English. Narrator: Bill Thatcher. Audio sample: http://samples.audible.de/bk/blak/009582/bk_blak_009582_sample.mp3. Digital audiobook in aax.
Cuba is more than just an exploration of culture, tourism, and people. It´s actually an excellent place to visit when it comes to historical significance from past to present, for generations to come. For instance, Cuban society is rich in influences, although Cuban customs greatly vary, which is dependent on certain cultural influences. This country is in fact located in the stunning Caribbean that comprises the mainland of Cuba called Isla de la Juventud, along with other archipelagos. Havana is actually the capital of Cuba and is known to be the largest city. On the nearby islands, you will see the Caicos Islands, Turks, and Bahamas on the northeastern part while the US is seen from the northern part of Cuba. Haiti is on the southeastern part, Jamaica and Cayman Islands on the south, and Mexico to the west. The country was also dwelled in by Amerindian clans prior to Christopher Columbus´ landing in 1492. Yet, Cuba continued to serve as a settlement for Spaniards until the onset of 1898´s Spanish-American War. Consequently, it achieved "nominal independence" as a US colony in the year 1902. The flimsy state suffered radical politics as well as social conflict despite the efforts of the people to strengthen their democratic system. Hence, Cuba was run by Fulgencio Batista´s dictatorship in 1952. Up to date, with the increasing popularity of this tourist destination in the beautiful island of the Caribbean, Cuba strives to offer a great relaxation and a vacation paradise to those who want to fulfill an ultimate escapade with the entire family. For people who love to explore the beauty of the Caribbean peninsula, this is the best place to visit for an unforgettable holiday experience. In terms of economy, Cubans actually enjoy a stable economic status as of today due to the growing popularity of the island to local and foreign visitors. Also, the universal healthcare system of Cuba has been considered by many as an... 1. Language: English. Narrator: Sangita Chauhan. Audio sample: http://samples.audible.de/bk/acx0/055005/bk_acx0_055005_sample.mp3. Digital audiobook in aax.