Certain stable lipid nanoemulsions display a marked capability for rapid active targeting, both to tumors and to certain lesion sites. This category of lipid nanoemulsions contains no phospholipids, no proteins nor peptides, no carbohydrates, and no chemical modification of the lipophilic drugs is required; consequently it avoids various problems reported for earlier versions of targeted nanoemulsions. The book covers in detail the underlying chemical and biochemical principles of stable lipid nanoemulsions as well as many applications in nanomedicine such as targeted chemotherapy. It is in harmony with goals of the current US National Nanotechnology Initiative, which include nanomedical approaches to drug delivery that focus on developing nanoscale particles to improve drug bioavailability i.e. often using targeted nanoparticles for delivering drugs with cell precision and less side effects. Despite the obvious practical importance to various fields including nanomedicine there is currently no comprehensive book available in the literature. The proposed book will effectively fill this gap.
A solid introduction to stable isotopes that can also be used as an instructive review for more experienced researchers and professionals. The book approaches the use of isotopes from the perspective of ecological and biological research, but its concepts can be applied within other disciplines. A novel, step-by-step spreadsheet modeling approach is also presented for circulating tracers in any ecological system, including any favorite system an ecologist might dream up while sitting at a computer. The authors humorous and lighthearted style painlessly imparts the principles of isotope ecology. The online material contains color illustrations, spreadsheet models, technical appendices, and problems and answers.
When Veronica diAngelo, a rider at Pine Hollow Stables, discovers that her stirrup leathers have been cut before an important hunter jumping exhibition, everyone assumes that practical joker Stevie Lake had something to do with it. After all, Stevie recently served her friends pancakes made out of plaster of Paris, and it´s a well-known fact that Stevie and the rest of The Saddle Club can´t stand snooty Veronica diAngelo. But would Stevie actually try to sabotage another rider -- and risk injuring her valuable Arabian? If Stevie didn´t cut Veronica´s leathers, then who did? Is it the work of a ´´witch´´ at the stable? And will The Saddle Club ever manage to dear Stevie´s name?
From the private to the historic to the state-of-the-art, a lavish tour of some of the most notable stables in the country. A celebration of horses and their ´´lodgings,´´ this exquisite book covers horse country across the United States--from the East Coast to the Bluegrass, the prairie and mountain ranches, and to the Pacific Coast--and traces the origins of twenty-five stunning stables, from their vernacular beginnings in the early nineteenth century to the contemporary designs of today. Included are a farm in the countryside near Saratoga Springs, New York, which bears an 1830s-constructed main barn that originally housed draft horses and now accommodates retired race horses turned polo ponies, and a world-renowned Arabian horse-breeding farm in Santa Ynez Valley, California, that resembles a spa and country club with Mediterranean-style architecture and landscaping and has in the stable courtyard a stone fountain reminiscent of the ubiquitous waterworks in Moorish palaces. Uniquely spectacular, each selection is a reflection of its regional heritage. Featuring all-new color photography, ´´Stables´´ showcases the best of America´s diverse equine homes--a must-have for any horse or architecture enthusiast.